PROPOD-100

Cefpodoxime proxetil 100 mg

Propod 100 (Cefpodoxime Proxetil) is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class. It is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. It is active against a wide-spectrum of Gram-positive and Gram-negative bacteria. It is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis.

Indications

• Acute otitis media
• Pharyngitis
• Tonsillitis
• Community-acquired pneumonia
• Acute bacterial exacerbation of chronic bronchitis
• Acute maxillary sinusitis
• Acute uncomplicated urethral and cervical gonorrhea
• Uncomplicated skin and skin structure infections
• Uncomplicated urinary tract infections

Dosage

Pharyngitis/tonsillitis : 100 mg every 12 hours for 10 days
Uncomplicated urinary tract infection : 100 mg every 12 hours for 7 days

Contraindications

Cefpodoxime Proxetil is contraindicated in patients with a known allergy to cefpodoxime or to the cephalosporin group of antibiotics

Precautions

• Before taking cefpodoxime proxetil, tell the doctor if you are allergic to it; or to penicillins or other cephalosporin antibiotics (e.g., cephalexin); or if you have any other allergies.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, stomach/intestinal disease (e.g., colitis). Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.
• During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
• This drug passes into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
• Prolonged use may result in super infection

Side effects

Diarrhea that is watery or bloody, fever, chills, body aches, flu symptoms, unusual bleeding or bruising, cough, wheezing, chest tightness, trouble breathing, fast or pounding heartbeats, seizure, pale or yellowed skin, dark colored urine, fever, confusion or weakness, jaundice (yellowing of the skin or eyes), sore throat, and headache with a severe blistering, peeling, and red skin rash, swelling, rapid weight gain, increased thirst, loss of appetite, urinating less than usual or not at all, nausea, vomiting, stomach pain, bloating, gas, constipation, stiff or tight muscles, back pain, muscle pain, headache, tired feeling, anxiety, nervousness, feeling restless or hyperactive, warmth or redness under your skin, dizziness, spinning sensation, nightmares, stuffy nose, dry mouth, unusual or unpleasant taste in the mouth, white patches or sores inside your mouth or on your lips, vaginal itching or discharge.

Drug interactions

• Decreased effects : Antacids and H2 receptor antagonists (reduce absorption and serum concentration of cefpodoxime)
• Increased effect : probenecid may decrease cephalosporin elimination
• Increased toxicity : Furosemide, aminoglycosides may be possible additive to nephrotoxicity