VOMITO (Drops)

Ondansetron 2 mg / 5ml

Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Ondansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

Ondansetron may be used for purposes not listed in this medication guide.

You should not use ondansetron if you are also using apomorphine (Apokyn).

You should not use ondansetron if you are allergic to it or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).

Before taking ondansetron, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome.

Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

Dosage

• The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor’s dosing instructions very carefully.

  Take the ondansetron regular tablet with a full glass of water.

  To take the orally disintegrating tablet (Zofran ODT):

  • Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
  • Use dry hands to remove the tablet and place it in your mouth.
  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
  • Swallow several times as the tablet dissolves.

  To use ondansetron oral soluble film (strip) (Zuplenz):

  • Keep the strip in the foil pouch until you are ready to use the medicine.
  • Using dry hands, remove the strip and place it on your tongue. It will begin to dissolve right away.
  • Do not swallow the strip whole. Allow it to dissolve in your mouth without chewing.
  • Swallow several times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip.
  • Wash your hands after using Zuplenz.

Before taking ondansetron, tell your doctor or pharmacist if you are allergic to it; or to other anti-nausea serotonin blockers (e.g., granisetron); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: irregular heartbeat, liver disease, stomach/intestinal problems (e.g., recent abdominal surgery, ileus, swelling).

Ondansetron may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

Side effects

Get emergency medical help if you have signs of an allergic reaction to ondansetron: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• severe constipation, stomach pain, or bloating;
• headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
• fast or pounding heartbeats;
• jaundice (yellowing of the skin or eyes);
• blurred vision or temporary vision loss (lasting from only a few minutes to several hours);
• high levels of serotonin in the body–agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

Common ondansetron side effects may include:

• diarrhea or constipation;
• headache;
• drowsiness; or
• tired feeling.

Drug interaction

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medication because a very serious interaction may occur: apomorphine.

If you are currently using the medication listed above, tell your doctor or pharmacist before starting ondansetron.

Before using this medication, tell your doctor of all nonprescription and prescription medication you may use, especially of: tramadol.

Ask your doctor or pharmacist for more details.