ACITO-P

Aceclofenac 100 mg + paracetamol 325 mg

Aceclofenac belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). These drugs fight against the inflammation and have painkiller properties. Aceclofenac acts by blocking the effect of enzyme cyclo oxygenase which blocks the production of hormone called prostaglandins which cause pain and inflammation.

Paracetamol is a non-salicylate analgesic and antipyretic. It is use to relieve mild to moderate pain. It blocks the production of prostaglandins in the brain and it also reduces fever through its action on the heat-regulating center of the brain.FDA approved paracetamol in 1951.

It has been demonstrated by recent studies of Pharmacotherapy that administration of combination (Aceclofenac + Paracetamol) showed rapid pain relief in Osteoarthritis as compared with monotherapy.

Indications

• Ankylosing spondylitis
• Rheumatoid Arthritis
• Dental pain
• Gynecological Pain

Dosage

Each tablet contains Aceclofenac 100 mg and paracetamol 325 mg. 1 tablet in the morning and 1 tablet in the evening. Maximum 2 tablets per day

Contraindications

Contraindicated in patients with severe ulcer, gastrointestinal bleeding, third trimester of pregnancy, severe heart failure, hypertension, hepatic impairment

Precautions

• Caution should be exercised in patients with history of GI disease, asthma or allergic disorders, hypertension, alcohol-dependent patients, blood clotting problems, cardiac impairment, Elderly.
• Do not drive a car or operate machinery while taking this medication because it may cause dizziness or drowsiness.
• Monitor renal and hepatic function and blood counts during long term treatment.

Side- effects

Diarrhea, Nausea, Headache, Indigestion, allergic reactions, skin rashes, acute renal tubular necrosis, vertigo, dizzies, nervousness, tinnitus, depression, drowsiness, insomnia; fever, angioedema, bronchospasm, rashes; blood dyscrasias, GI bleeding, nephrotoxicity

Drug interaction

Aceclofenac can increase the plasma concentration of digoxin and lithium. It may inhibit the activity of diuretics. May enhance activity of anticoagulants. Increase nephrotoxicity with diuretics. Serum-potassium should be monitored when used with potassium-sparing diuretics. Co-administration of aceclofenac with other NSAIDs and corticosteroids are to be avoided.

Paracetamol reduced the absorption of cholestyramine within 1 hr of administration whereas accelerated absorption with metoclopramide. Co-administration of paracetamol with epileptic drugs, rifampicin, isoniazid, antiviral, chloramphenicol is to be avoided.