OMISAN-RD

Esomeprazole 40 mg + Domperidone 30 mg (Sustained Release) Capsule

1. Esomeprazole magnesium oral capsule is available as a brand-name drug and a generic drug. Brand name: Nexium.
2. Esomeprazole comes in three forms. Esomeprazole magnesium and esomeprazole strontium are available as delayed-release capsules. Esomeprazole magnesium is also available as a liquid suspension. Esomeprazole sodium is available in an intravenous (IV) form, which is only given by a healthcare provider.
3. Esomeprazole magnesium oral capsule is used to treat conditions caused by too much acid production in your stomach. These conditions include gastroesophageal reflux disease (GERD), erosive esophagitis, Zollinger-Ellison syndrome, and Helicobacter pylori infections. It’s also used to prevent stomach ulcers due to the use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Important warnings

• Kidney damage warning: This drug may cause kidney damage. Tell your doctor if you have pain in the side of your back or changes in urination during treatment. These are signs of kidney problems.
• Severe diarrhea warning: This drug can cause Clostridium difficile-associated diarrhea. This may result in mild diarrhea or severe inflammation of your colon. Severe reactions can be fatal (cause death). Call your doctor if you have diarrhea while taking this drug.
• Long-term use warning: Using this drug for a long time comes with risks. It increases your risk of osteoporosis-related bone breaks in your hip, wrist, or spine. It may also cause inflammation of your stomach lining and low blood levels of magnesium. Taking this drug long term can also make it harder for your body to absorb vitamin B-12. This can lead to a vitamin B-12 deficiency. Talk to your doctor about how long you can safely take this drug.
• CLE and SLE warning: Esomeprazole can cause cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). CLE and SLE are autoimmune diseases. Symptoms of CLE can range from a rash on the skin and nose, to a raised, scaly, red or purple rash on certain parts of the body. Symptoms of SLE can include fever, tiredness, weight loss, blood clots, heartburn, and stomach pain. If you have any of these symptoms, call your doctor.

Dosage

Adult dosage (ages 18 years and older)

Typical dosage is 40 mg taken twice per day. Sometimes doses up to 240 mg per day are needed.

Child dosage (ages 0 to 17 years)

This drug hasn’t been studied in children younger than 18 years for this condition.

Special dosage considerations

For people with severe liver problems: The maximum dosage of esomeprazole magnesium shouldn’t be more than 20 mg per day.

Take this drug as directed by your doctor. Your doctor should give you the drug at the lowest dosage possible and for the shortest time needed. This will lower your risk of side effects.

Side effects

The adult side effects for esomeprazole magnesium are slightly different from the side effects for children.

Adult side effects can include:

• headache
• diarrhea
• nausea
• flatulence (passing gas)
• stomach pain
• constipation
• dry mouth

Children’s side effects can include the above, plus:

• regurgitation (burping up food) in babies
• increased breathing rate in babies

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Severe diarrhea. Symptoms can include:
  • watery stool
  • stomach pain
  • fever that doesn’t go away

Drug interaction

Esomeprazole magnesium oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with esomeprazole magnesium are listed below.